Topoisomerase inhibitor camptothecin sen
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Hannes Hentze; Markus Latta; Gerald KΓΌnstle; Saravanakumar Dhakshinamoorthy; Poh
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Article
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2004
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John Wiley and Sons
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English
β 460 KB
Topoisomerases are nuclear enzymes that maintain and modulate DNA structure. Inhibitors of topoisomerases like camptothecin (CPT), etoposide, and others are widely used antitumor drugs that interfere with transcription, induce DNA strand breaks, and trigger apoptosis preferentially in dividing cells