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Hydrogen ion concentration differentiates effects of methamphetamine and dopamine on transporter-mediated efflux

โœ Scribed by Clare J. Wilhelm; Robert A. Johnson; Amy J. Eshleman; Aaron Janowsky

Book ID
111179346
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
362 KB
Volume
96
Category
Article
ISSN
0022-3042

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Drug-induced efflux of substrates was characterized in C6 rat glioma cells stably expressing a recombinant human dopamine (DA) or serotonin (5-HT) transporter (C6-hDAT and C6-hSERT, respectively). In the absence of Ca 2ฯฉ , these cells spontaneously and rapidly released preloaded [ 3 H]DA or [ 3 H]5-