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Hydrogen exchange kinetics of proteins in denaturants: a generalized two-process model

โœ Scribed by Hong Qian; Sunney I. Chan


Book ID
115629073
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
229 KB
Volume
286
Category
Article
ISSN
0022-2836

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## Abstract In proton nmr, the chemical exchange rates of slowly exchanging labile hydrogens (with lifetimes in the range โˆผ 10 msec โ€“ โˆผ 1 sec) of peptides, proteins, and nucleic acids can be measured in H~2~O by a combination of two separate experiments: (1) the transfer of solvent saturation and (