Hydrogen bonding control of self-assembly: Simple isophthalic acid derivatives form cyclic hexameric aggregates
✍ Scribed by Ji Yang; Jean-Luc Marendaz; Steven J. Geib; Andrew D. Hamilton
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 290 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
In this paper we demonstrate that six molecules of a functionalized isophthalic acid de&alive farm a cyclic aggregate stabilized by a network of 12 hydrogen bonds. The structure and stability of the aggregate wete studied by X-ray ~s~o~hy, vapor phase osmometry and tH MMR,
The design of small molecular components that form well-defined and stable aggregates in solution is an area of intense ctumnt interest.1~ Some insight into how this might be achieved can come from consideration of the crystal sauctu~ packing pattems of hydrogen bonding moIecu1es.f~~ For example, the X-ray structure of ttimesic acid shows an infinite sheet mgement in which each molecule forms six hydrogen bonds m three neighboring residues (Figure Q-5 The tw&ing hexagonal-lattice structure leads m large cavities each bounded by six trimesic acid molecules.