KNOWLEDGE of the effects of amine substituents on chemical shifts and coupling constants is important in elucidating the distributions of dissociable protons and rotamers in amino acids and other amine compounds at various pH values. In previous studies of 2,5-dimethylpiperazine and its hydrochlorid
β¦ LIBER β¦
Hydrogen bonding and geminal proton coupling
β Scribed by Kim F Wong; Soon Ng
- Publisher
- Elsevier Science
- Year
- 1974
- Weight
- 261 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0022-2364
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The two-bond "N,H coupling constant in 3,5dimethylpyridine was determined in 30 solvents and shown to vary between -11 and -3 Hz. An increasing ability of the solvent to form hydrogen bonds causes a steady decrease in I \*J("N,H) I , which is also observed with some selected pyridine derivatives wit