Hydrogen bond among the ionic groups of ampholytic phospholipid

✍ Scribed by T. Seimiya; M. Ashida; M. Hayashi; T. Muramatsu; I. Hara

• Publisher: Elsevier Science
• Year: 1978
• Tongue: English
• Weight: 665 KB
• Volume: 21
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(78)90055-5

✦ Synopsis

The nature of interaction among t.he i6nic g~oups of lipids was studied by proton NMR meamrements for ampholytic analogues of phosphoh'pids, each dHf~ring in s~ctural separadon between PO?~ and NI~ groups, Single resonance ~s observ~ for the ionic p~otons of lJpids in deuterochloroform indicate the rapid exchange of protons between POoH and NH~, and showed that the two groups interact intramolecularly and/or intermo|ecule~ly by forming a hydrogea bond.

The hydrogen bond is found to be weak for dipalmitoylphosphafidyl-p~¢,panolamine and -butanolamine but strong for bath the -ethanolamine and -pentanotamme. q~he hydrogen b<md counteracts with calcium bint~ing and is almost broken for calcium complexes of the li~ id,~.