Hydrogels for buccal drug delivery: Properties relevant for muco-adhesion

✍ Scribed by de Vries, M. E. ;Boddé, H. E. ;Busscher, H. J. ;Junginger, H. E.

• Book ID: 102293090
• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 473 KB
• Volume: 22
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.820221106

✦ Synopsis

In order to develop a muco-adhesive hydrogel for buccal drug delivery it is necessary to understand fully the properties determining adhesiveness a s well a s mechanisms involved. In this study we measured glass transition temperatures, water contact angles and the peel-and shear detachment forces from porcine oral mucosa, of acrylic acid and butyl acrylate copolymers. The contact angle maximizes at 50% butyl acrylate content. The glass transition temperature decreases from 0% to 100% butyl acrylate. There seems to exist a certain combination of contact angle and glass transition temperature which is related to adhesiveness. This strongly suggests that, in order to obtain a muco-adhesive hydrogel, at least two properties have to be optimized:

(1) the polarity of the polymer surface and (2) the molecular mobility of the polymer groups.