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Hydrogels and drug delivery

✍ Scribed by Nikolaos A Peppas

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
663 KB
Volume
2
Category
Article
ISSN
1359-0294

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✦ Synopsis

Recent developments include the use of water-swollen, crosslinked biomedical polymers as carriers for the delivery of drugs, peptides and proteins, as targeting agents for site-specific delivery, or as components for preparation of protein or enzyme conjugates. The network structure and the thermodynamic nature of the components of these networks playa key role in their diffusional behavior, molecular mesh size changes (especially in environmentally responsive hydrogels), and the associated molecular stability of the incorporated bioactive agents.

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## Abstract Stem cells, progenitor cells, and lineage‐committed cells are being considered as a new generation of drug depots for the sustained release of therapeutic biomolecules. Hydrogels are often used in conjunction with the therapeutic secreting cells to provide a physical barrier to protect