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Hydrodynamics-based transfer of PCR-amplified DNA fragments into rat liver

✍ Scribed by S Kameda; H Maruyama; N Higuchi; G Nakamura; N Iino; Y Nishikawa; J Miyazaki; F Gejyo

Book ID
116287004
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
338 KB
Volume
309
Category
Article
ISSN
0006-291X

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πŸ“œ SIMILAR VOLUMES

Hydrodynamics-based transfection of the
Hydrodynamics-based transfection of the liver: entrance into hepatocytes of DNA that causes expression takes place very early after injection
✍ Fanjam Andrianaivo; MichΓ¨le Lecocq; Simone Wattiaux-De Coninck; Robert Wattiaux; πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 127 KB

## Abstract ## Background The mechanism of gene transfer into hepatocytes by the hydrodynamics‐based transfection procedure is not clearly understood. It has been shown that, after a hydrodynamic injection, a large proportion of plasmid DNA remains intact in the liver where it is bound to plasma m