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Hydrodynamic and mass transfer study of a gas-liquid-solid draft tube spouted bed bioreactor

✍ Scribed by D.G. Karamanev; T. Nagamune; I. Endo

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
652 KB
Volume
47
Category
Article
ISSN
0009-2509

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✦ Synopsis

It has already been proved that the soft polyurethane foam particles are very effective carriers for immobilizing fungi and/or mycelia. However, the classic three phase fluid&d bed bioreactor was not effective enough for the production of antibiotics like penicillin due to the lower value of the mass transfer rate of oxygen. In order to improve this parameter, we introduced a draft tube in the reactor thus obtaining a gas-liquid-solid draft tube spouted bed bioreactor. The effect of both design and operational parameters on the mass transfer rate of oxygen was studied experimentally. It was shown that the volumetric mass transfer rate of oxygen in the new bioreactor was increased between 1.5 and 3 times as compared to a conventional three phase fluidixed bed. Indications for scaling-up of the bioreactor for industrial use were also obtained.

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✍ Vidya Shetty Kodialbail; Govindan Srinikethan πŸ“‚ Article πŸ“… 2011 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 401 KB

## Abstract **BACKGROUND:** The pulsed plate column (PPC) with packed bed of solids in the interplate spaces finds use as a three phase aerobic bioreactor and is a potential heterogeneous catalytic reactor. Good knowledge of the extent of mixing in the liquid phase and solid‐liquid mass transfer co