Several studies have shown that promethazine can reduce age-related osteopenia in mice. Furthermore, prolonged treatment with promethazine (50 mg/day) increases bone mineral content in the lumbar spine in post-menopausal women with osteopenia. However, the mechanism of action of promethazine has not
Hydrochlorothiazide inhibits osteoclastic bone resorptionIn vitro
β Scribed by T. J. Hall; M. Schaueblin
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 241 KB
- Volume
- 55
- Category
- Article
- ISSN
- 1432-0827
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We have examined the effect of the anti-tumor compound taxol, on osteoclastic bone resorption. In the bone slice assay, taxol (0.1-0.001 microM) dose-dependently inhibited bone resorption with an IC50 of 0.08 microM. Osteoclast survival on bone slices was unaffected by 0.01-1 microM taxol, but 10 mi
The effects of Zeolite A on bone resorbing activity of highly purified avian osteoclasts were analyzed. The present study demonstrates that when 100 pg/ml of acid-treated Zeolite A is added to the media the number of pits per osteoclast is reduced 3-fold at 24 h after treatment. Secreted cathepsin B