𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Hydration, stability, and phase transformations of a new antitumor drug

✍ Scribed by A. Marini; V. Berbenni; G. Bruni; P. Cofrancesco; C. Margheritis; A. Orlandi; M. Villa

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
261 KB
Volume
93
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

We studied hydration equilibria and phase transformations in a cytotoxic drug (BBR3576). The original sample is a hydrated compound that undergoes a structural phase transition when it looses about half of its structural water. Such a structural transition is completely reversible: the partially dehydrated form is stable up to 1308C (or up to 1408C for several minutes) and reverts to the original form upon rehydration. Completely different phase relationships are observed if an original sample is fully dehydrated: when all water has been released, a metastable anhydrous phase forms, which undergoes an irreversible exothermic conversion to a stable phase. Upon rehydration at room temperature of such an anhydrous phase, a new hydrated form is obtained, which is definitely different from the original one.

πŸ“œ SIMILAR VOLUMES

Crystalline and amorphous phases of a ne
Crystalline and amorphous phases of a new drug
✍ G. Bruni; C. Milanese; V. Berbenni; F. Sartor; M. Villa; A. Marini πŸ“‚ Article πŸ“… 2009 πŸ› Springer Netherlands 🌐 English βš– 546 KB
The role of hydration in enzyme activity
The role of hydration in enzyme activity and stability: 2. Alcohol dehydrogenase activity and stability in a continuous gas phase reactor
✍ Fangxiao Yang; Alan J. Russell πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 717 KB

The degree of enzyme hydration is the one of the most important factors which can affect enzyme activity and stability in water-limited environments. Alcohol dehydrogenase from baker's yeast (YADH) has been used as a model enzyme to study the effects of hydration on activity, stability, and cofactor