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Hydration of short DNA, RNA and 2'-OMe oligonucleotides determined by osmotic stressing

✍ Scribed by Rozners, E.


Book ID
121687085
Publisher
Oxford University Press
Year
2004
Tongue
English
Weight
145 KB
Volume
32
Category
Article
ISSN
0305-1048

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The cytotoxic effects of cisplatin, cis-diamminedichloroplatinum(II), are generally ascribed to the formation of DNA adducts. Several in vitro as well as in vivo studies showed that cisplatin binds preferentially to guanines belonging to (G) n sequences (n > 2). After mono-or diaquation of cisplatin