✦ LIBER ✦
Hydration of 2-Isoxazoline Leading to a Stable 3,5,5-Trisubstituted 3-Isoxazolidinol − N-Acylated Derivatives and Ring-Chain Tautomerism Study
✍ Scribed by Cornelia Uncuţa; Adriana Tudose; Miron T. Căproiu; Silvia Udrea; Christian Roussel
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 122 KB
- Volume
- 2002
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
A new 2-isoxazoline ring-opening pathway leading to β-(acylaminooxy) ketones 9 is described. It occurred through covalent hydration of the C-N double bond giving stable 3isoxazolidinol 5, followed by acylation with anhydrides. The ring-chain tautomerism of 3-isoxazolidinol 5 in comparison