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Hydrated Tetrabutylammonium Fluoride as a Powerful Nucleophilic Fluorinating Agent

✍ Scribed by Albanese, Domenico; Landini, Dario; Penso, Michele


Book ID
121225593
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
39 KB
Volume
63
Category
Article
ISSN
0022-3263

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Facile nucleophilic fluorination of prim
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Nonpolar protic reaction media such as t-amyl alcohol allow the aliphatic, nucleophilic fluorination reaction of primary haloalkane systems to fluoroalkanes, using tetrabutylammonium fluoride (TBAF), to proceed chemo-selectively at a reasonable reaction rate under mild conditions to afford the fluor