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Hybridization to oligonucleotide arrays for the assessment of gene copy number

✍ Scribed by Baldocchi, Russ; Glynne, Richard; Kowbel, Dave; Tom, Ed; Collins, Colin; Mack, David; Gray, Joe


Book ID
109830351
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
32 KB
Volume
27
Category
Article
ISSN
1061-4036

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Genomic copy-number variations (CNVs) involving large DNA segments are known to cause many genetic disorders. Depending on the changes, they are predicted to lead either to decreased or an increased gene expression. However, the ability to detect smaller exonic copy-number changes has not been explo