## Abstract Combined analysis of gene expression array data and arrayβbased comparative genomic hybridization data have been used in a series of 26 pediatric brain tumors to define upβ and downregulated genes that coincide with losses, gains, and amplifications involving specific chromosome regions
Hybridization to oligonucleotide arrays for the assessment of gene copy number
β Scribed by Baldocchi, Russ; Glynne, Richard; Kowbel, Dave; Tom, Ed; Collins, Colin; Mack, David; Gray, Joe
- Book ID
- 109830351
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 32 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/86992
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## Communicated by Mireille Claustres Genomic imbalance is a major cause of developmental disorders. Microarray-based comparative genomic hybridization (aCGH) has revealed frequent imbalances associated with clinical syndromes, but also a large number of copy number variations (CNVs), which have co
Genomic copy-number variations (CNVs) involving large DNA segments are known to cause many genetic disorders. Depending on the changes, they are predicted to lead either to decreased or an increased gene expression. However, the ability to detect smaller exonic copy-number changes has not been explo