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Hybridization of somatic cells derived from mouse and Syrian hamster: Evolution of karyotype and enzyme studies

✍ Scribed by Barbara Ruben Migeon

Publisher
Springer
Year
1968
Tongue
English
Weight
769 KB
Volume
1
Category
Article
ISSN
0006-2928

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✦ Synopsis

Somatic hybrids of drug-resistant mutant hamster and mouse cell lines have been isolated and propagated in long-term culture and have been studied in respect to karyotype and three enzymes. During the course of propagation the long-surviving hybrid clones show progressive loss of telocentric chromosomes associated in at least one case with loss of mouse enzyme. Hybrid clones showed hybrid molecules for malate dehydrogenase (MDH), lactate dehydrogenase (LDH), and 6-phosphogluconate dehydrogenase (6PGD) made up by recombination of parental subunits.

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