Hybrid α/β-peptides: For-Met-Leu-Phe-OMe analogues containing geminally disubstituted β2,2- and β3,3-amino acids at the central position

Hybrid α/β3-peptides with proteinogenic

Hybrid α/β3-peptides with proteinogenic side chains. monosubstituted analogues of the chemotactic tripeptide For-Met-Leu-Phe-OMe

✍ Cesare Giordano; Gino Lucente; Adriano Mollica; Marianna Nalli; Giampiero Pagani 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 267 KB

## Abstract The α/β^3^‐mixed tripeptides R‐CO‐β^3^‐HMet‐Leu‐Phe‐OMe (**1a**,**b**), R‐CO‐Met‐β^3^‐HLeu‐Phe‐OMe (**2a**,**b**) and R‐CO‐Met‐Leu‐β^3^‐HPhe‐OMe (**3a**,**b**) (**a**, R = __tert__‐butyloxy‐; **b**, R = H−), analogues of the potent chemoattractant For‐Met‐Leu‐Phe‐OMe, have been synthesi