๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Hybrid framework for hazard identification and assessment in batch processes

โœ Scribed by S. Viswanathan; N. Shah; V. Venkatasubramanian


Publisher
American Institute of Chemical Engineers
Year
2002
Tongue
English
Weight
237 KB
Volume
48
Category
Article
ISSN
0001-1541

No coin nor oath required. For personal study only.

โœฆ Synopsis


Abstract

A framework presented addresses the three main parts of a process hazards analysis study: hazard identification, hazard evaluation, and hazard mitigation. The framework utilizes a hybrid methodology that effectively combines a qualitative digraph modelโ€based technique for performing hazard identification and a quantitative optimizationโ€based technique for performing hazard evaluation and hazard mitigation. The combined framework circumvents the local minima problems faced by mathematical optimization algorithms, as well as the qualitative ambiguities that plague digraph models. The systems used to implement the framework are BatchHAZOPExpert, gPROMS, and gOPT. BatchHAZOPExpert is used for hazard identification, while gPROMS and gOPT are used for hazard evaluation and hazard mitigation. The application of the integrated framework is illustrated by implementing it on two industrial case studies.


๐Ÿ“œ SIMILAR VOLUMES


A framework for assessing the solutions
โœ John R Joseph; Andrew Sinclair; Nigel J Titchener-Hooker; Yuhong Zhou ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 420 KB

## Abstract Chromatographic separation of biopharmaceuticals is complex and tools for the prediction of performance and the tradeโ€offs necessary for efficient operation are limited and timeโ€consuming. This complexity is due to the large number of possible column aspect ratios that satisfy process a