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Hybrid anthracyclines by a genetically engineered Streptomyces galilaeus mutant

✍ Scribed by Tero Kunnari; Jarmo Niemi; Kristiina Ylihonko; Pekka Mäntsälä; Juha Hakala

Book ID: 104364904
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 114 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(97)00092-9

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✦ Synopsis

A Streptomyces galilaeus mutant carrying genes transfered from S. purpurascens is reported to produce two hybrid anthracyclines. This study demonstrates the possibility of producing hybrid anthracyclines in a combinatorial way by genetic engineering of anthracycline producing strains.

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