It has been established that fragmented hyaluronic acid (HA), but not native high molecular weight HA, can induce angiogenesis, cell proliferation and migration. We have studied the outside-in signal transduction pathways responsible for fragmented HA-mediated cancer cell invasion. In our study, we
Hyaluronic acid/CD44H interaction induces cell detachment and stimulates migration and invasion of human glioma cells in vitro
β Scribed by Shahriar Koochekpour; Geoffrey J. Pilkington; Abderrahim Merzak
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 825 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0020-7136
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## Abstract Focal adhesion kinase (FAK) and hypoxiaβinducible factor (HIFβ1Ξ±) are both upβregulated in glioblastoma multiforme (GBMs), particularly in invasive zones. Because FAK may play an important role in the invasion of glioma cells into the surrounding brain, we sought an agent that causes do