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Hyaluronic acid abrogates nitric oxide-dependent stimulation of collagen degradation in cultured human chondrocytes

✍ Scribed by Arkadiusz Surazynski; Wojciech Miltyk; Robert Czarnomysy; Joanna Grabowska; Jerzy Palka

Book ID: 119346636
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 398 KB
Volume: 60
Category: Article
ISSN: 1043-6618
DOI: 10.1016/j.phrs.2009.03.009

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## Abstract Nitric oxide (NO) from astrocytes is one of the signalers used by the brain's extensive glial‐neuronal‐vascular network, but its excessive production by pro‐inflammatory cytokine‐stimulated glial cells can be cytodestructive. Here, we show how three pro‐inflammatory cytokines (IL‐1β, TN