Hyaluronan-Mediated Leukocyte Adhesion and Dextran Sulfate Sodium-Induced Colitis Are Attenuated in the Absence of Signal Transducer and Activator of Transcription 1

Mucin-depleted foci show strong activati

Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate

✍ Angelo Pietro Femia; Piero Dolara; Cristina Luceri; Maddalena Salvadori; Giovann 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 324 KB

## Abstract Mucin‐depleted foci (MDF), formed by dysplastic crypts devoid of mucins, have been identified in the colon of carcinogen‐treated rodents and in humans at high risk for colon cancer. The lack of the protective layer of mucus may cause inflammation which has been linked to colon carcinoge