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Hyaluronan fragments activate nitric oxide synthase and the production of nitric oxide by articular chondrocytes

✍ Scribed by Stanca Iacob; Cheryl B. Knudson

Book ID
116307071
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
369 KB
Volume
38
Category
Article
ISSN
1357-2725

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Hepatic injury and chronic wounding are characterized by increased synthesis of extracellular matrix proteins including hyaluronan (HA). Recently, it has been recognized that low-molecular-weight fragments of HA, but not native HA (e.g., high-molecular-weight HA), induce inflammatory gene expression