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Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation

✍ Scribed by Back, Stephen A; Tuohy, Therese M F; Chen, Hanqin; Wallingford, Nicholas; Craig, Andrew; Struve, Jaime; Luo, Ning Ling; Banine, Fatima; Liu, Ying; Chang, Ansi; Trapp, Bruce D; Bebo,, Bruce F; Rao, Mahendra S; Sherman, Larry S

Book ID
109932593
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
729 KB
Volume
11
Category
Article
ISSN
1078-8956

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Oligodendrocyte progenitors originate in the subventricular zone, proliferate, migrate to their final destinations, differentiate, and interact with axons to produce multilamellar myelin sheaths. These processes are regulated by a variety of environmental signals, including growth factors, the extra