A homozygous ZMPSTE24 null mutation in c
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Jonas Denecke; Thomas Brune; Tobias Feldhaus; Horst Robenek; Christian Kranz; Ri
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Article
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2006
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John Wiley and Sons
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English
β 347 KB
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A