Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons
β Scribed by Jin Zhou; Xi Can Tang
- Book ID
- 117104486
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 301 KB
- Volume
- 526
- Category
- Article
- ISSN
- 0014-5793
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## Abstract Huperzine A, a novel __Lycopodium__ alkaloid originally discovered in the Chinese herb Qian Ceng Ta (__Huperzia serrata__), is a reversible, potent, and selective acetylcholinesterase (AChE) inhibitor and has been extensively used for the treatment of Alzheimer's disease (AD) in China.
Mitochondria play a critical role in cell death by releasing apoptogenic factors, such as cytochrome c and apoptosis-inducing factor (AIF), from the intermembrane space into the cytoplasm. Because mitochondrial dysfunction has been shown to be involved in several neurodegenerative diseases, mitochon