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Huntington's disease: molecular basis of neurodegeneration

✍ Scribed by Rubinsztein, David C.; Carmichael, Jenny

Book ID: 111890641
Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 201 KB
Volume: 5
Category: Article
ISSN: 1574-6976
DOI: 10.1017/s1462399403006549

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Huntington's disease (HD) is a progressive neurodegenerative disease striking principally medium spiny GABAergic neurons of the caudate nucleus of the basal ganglia. It affects about one in 10,000 individuals and is transmitted in an autosomal dominant fashion. The molecular basis of the disease is