𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Huntington's disease: biochemical prediction by determination of GABA synthesis of cultured fibroblasts

✍ Scribed by G. Göhlich; W. Kuhn; H. Höhn; H. Przuntek

Book ID
104717923
Publisher
Springer
Year
1984
Tongue
English
Weight
272 KB
Volume
231
Category
Article
ISSN
0340-5354

No coin nor oath required. For personal study only.

✦ Synopsis

GABA synthesis in skin fibroblasts from patients with Huntington's chorea was compared with that in a control group by means of the highly specific 3H-muscimol radioreceptor assay. A significantly increased rate of GABA synthesis was found in the group with Huntington's chorea in an early cell passage. The possible use of this method for early diagnosis of Huntington's chorea is considered.

📜 SIMILAR VOLUMES

Huntington's disease—growth of fibroblas
Huntington's disease—growth of fibroblast cultures in lipid-deficient medium: A preliminary report
✍ Dr. John H. Menkes; Amalia Hanoch 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 276 KB 👁 2 views

## Abstract When skin fibroblast cultures derived from subjects with Huntington's disease (HD) were grown in medium supplemented with lipid‐deficient serum (LDS), growth rates were less than those of control cultures. The mean percentage increase in generation time for nine control cultures incurre