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Huntington's chorea—Measurements of somatostatin, substance P and Cyclic nucleotides in the cerebrospinal fluid

✍ Scribed by H. Cramer; J. Kohler; G. Oepen; G. Schomburg; E. Schröter

Publisher
Springer
Year
1981
Tongue
English
Weight
303 KB
Volume
225
Category
Article
ISSN
0340-5354

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✦ Synopsis

Somatostatin, substance P, cyclic AMP and cyclic GMP were determined in the cerebrospinal fluid of patients with Huntington's disease, in first generation relatives of choreic patients and in neurological control patients. Substance P levels were not significantly altered, but somatostatin levels were markedly decreased both in affected patients and symptom-free offspring. Cyclic AMP was decreased only in patients with advanced stages of the disease while cyclic GMP was normal. Evidence is discussed which may support a role of somatostatin deficiency in the pathophysiology of chorea.

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