Truncated APC is required for cell proli
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Jean Schneikert; JΓΌrgen Behrens
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Article
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2006
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John Wiley and Sons
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French
β 331 KB
## Abstract The tumour suppressor APC is truncated in most colon cancers, which leads to the stabilization of Ξ²βcatenin and to the constitutive activation of Wnt signalling. However, it is not clear why colon cancer cells retain the truncated APC fragment. Here, we show that a decrease of APC level