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Humoral immune responses against norovirus infections of children

✍ Scribed by Nobuhiro Iritani; Toshiyuki Seto; Hideji Hattori; Katsurou Natori; Naokazu Takeda; Hideyuki Kubo; Tsunekazu Yamano; Minoru Ayata; Hisashi Ogura; Yoshiyuki Seto

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
122 KB
Volume
79
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

In 2 infants with gastroenteritis associated with Norovirus (NoV), serum immunoglobulin (Ig) G, IgM, IgA, and fecal IgA antibody responses against NoV were examined by enzyme‐linked immunosorbent assay using 11 different antigenic and genetic types of NoV virus‐like particles expressed in insect cells. These two cases were putative primary single NoV infections, because antibodies against NoVs were not detected in acute‐phase serums. In one of two cases, long‐term excretion of virus RNA for 33 days was observed. Serum IgG responses demonstrated strong seroresponse to the homologous type, and weak seroresponse to the heterologous types within the genogroup. After more than 2 years, the IgG antibody titer remained high to the homologous type and low to the heterologous type within the genogroup. IgM and IgA were specific to the homologous type. IgM was short lived and the serum IgA antibody titer remained low to the homologous type for a long period. These results improve our understanding of the humoral immune response to NoV infection. J. Med. Virol. 79: 1187–1193, 2007. © 2007 Wiley‐Liss, Inc.

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