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Humoral immune response in disease-free advanced melanoma patients after vaccination with melanoma-associated gangliosides

✍ Scribed by Jacques Portoukalian; Stefan Carrel; Jean-François Doré

Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 761 KB
Volume: 49
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910490616

No coin nor oath required. For personal study only.

✦ Synopsis

Number of melanoma metastases surgically removed prior to treatment.-2Form of ganglioside vaccine ~tilized.-~Antibody response (Ab) to the vaccine.-'Relapses and 'Disease-free interval expressed in weeks.

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Two HLA-A2-positive patients with advanced stage IV melanoma were treated with monocyte-derived dendritic cells (DC) pulsed with either tumor peptide antigens from gp100, MART-1 and MAGE-3 alone or in combination with autologous oncolysates. Clinically, the rapid progression of disease was substanti