Humoral hypercalcemia of malignancy: Some enigmas on the clinical features

✍ Scribed by Kyoji Ikeda; Etsuro Ogata

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 783 KB
• Volume: 57
• Category: Article
• ISSN: 0730-2312
• DOI: 10.1002/jcb.240570303

✦ Synopsis

Humoral hypercalcemia of malignancy (HHM) is a common paraneoplastic syndrome mediated by tumor-derived parathyroid hormone-related peptide (PTHRP), which bears structural and functional similarities to PTH.

Thus the clinical features of HHM are very similar to those of primary hyperparathyroidism ( I " HPT), a prototype of humordl hypercalcemia caused by PTH. On the other hand, HHM syndrome differs from 1" HPT in several aspects, including serum 1,2.5(OH)2D levels, acid-base balance, and bone remodeling process, the reason of which remains largely unknown. We approached these questions using a unique animal model of HHM, nude rats implanted with PTHRP-overproducing human carcinomas. In this review we will summarize the results and discuss the implications in understanding the disease mechanism. ', 1995 WiIey-Liss, Inc.