## Abstract A human monoclonal anti‐idiotypic antibody (105AD7) has been developed which mimics a colorectal‐tumour‐associated antigen and induces cellular anti‐colorectal tumour immune responses in animals. Thirteen patients with advanced colorectal cancer were immunized with 105AD7 and their surv
Humoral anti-idiotypic and anti-anti-idiotypic immune response in cancer patients treated with monoclonal antibody 17-1A
✍ Scribed by Jan Fagerberg; Peter Ragnhammar; Maria Liljefors; Anna-Lena Hjelm; Håkan Mellstedt; Jan-Erik Frödin; J. Fagersberg
- Publisher
- Springer-Verlag
- Year
- 1996
- Tongue
- English
- Weight
- 137 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0340-7004
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We have previously described the tumor-asrocisited sialoglycoprotein antigen sGP,,,, defined by the murine LAME MAb. The antigen is characterized by strong memlbrane expression in a proportion of small-cell carcinomas of the lung, but little or no expression on normal tissues of epithelial or neural
## Abstract We have previously developed 3 monoclonal anti‐idiotypic antibodies (Ab2) of LOU rat origin directed against the binding site of the murine monoclonal IgM LAM8, which recognizes the small‐cell lung carcinoma (SCLC)‐associated sialoglycoprotein antigen sGP~90–135~. The aim of this study