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Humanized Knock-In Mice Expressing Chimeric Prion Protein Showed Varied Susceptibility to Different Human Prions

✍ Scribed by Yuzuru Taguchi; Shirou Mohri; James W. Ironside; Tamaki Muramoto; Tetsuyuki Kitamoto


Book ID
117021761
Publisher
American Society for Investigative Pathology
Year
2003
Tongue
English
Weight
625 KB
Volume
163
Category
Article
ISSN
0002-9440

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## Abstract Prion diseases are characterized by high accumulation of infectious prion proteins (PrP^Sc^) in brains. PrP^Sc^ are propagated by the conversion of host‐encoded cellular prion proteins (PrP^C^) which are essential for developing the disease but are heterogeneously expressed in brains. T