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Humanization of mouse ONS-M21 antibody with the aid of hybrid variable regions

✍ Scribed by Toshihiko Ohtomo; Masayuki Tsuchiya; Koh Sato; Keiji Shimizu; Syusuke Moriuchi; Yasuyoshi Miyao; Toshio Akimoto; Ken-Ichi Akamatsu; Toru Hayakawa; Yoshiyuki Ohsugi


Book ID
116097612
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
1008 KB
Volume
32
Category
Article
ISSN
0161-5890

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✍ Anabelle Sequeira; Stratis Avrameas; Evelyne Jouvin-Marche πŸ“‚ Article πŸ“… 1992 πŸ› Springer-Verlag 🌐 English βš– 640 KB

The complete nucleotide sequences of heavy and light chains of a mouse polyreactive IgG2b antibody were determined. This antibody, obtained after primary immunization of BALB/c mice with human lymphoblastoid cells, possess anti-HLA-DR and anti-rheumatoid factor activities and reacts with various sel