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Human Δ4-3-oxosteroid 5β-reductase (AKR1D1) deficiency and steroid metabolism

✍ Scribed by Mario Palermo; Maria Grazia Marazzi; Beverly A. Hughes; Paul M. Stewart; Peter T. Clayton; Cedric H.L. Shackleton

Book ID: 116892130
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 252 KB
Volume: 73
Category: Article
ISSN: 0039-128X
DOI: 10.1016/j.steroids.2007.12.001

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## Abstract Homologs of 17‐hydroxy‐4,4‐17α‐trimethyl‐3‐oxo‐androst‐5‐ene‐2α‐carbonitrile (**6d**), such as the 4,4‐diethyl‐(**6a**), 4,4‐cyclopentyl‐(**6c**) and 4,4‐cyclohexyl‐(**6b**) analogs were synthesized.