𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Human αB-crystallin (CRYA2) gene mapped to chromosome 11q12-q23

✍ Scribed by Ruud H. Brakenhoff; Ad H. M. Geurts Kessel; Margot Oldenburg; Jules T. Wijnen; Hans Bloemendal; P. Meera Khan; John G. G. Schoenmakers

Publisher
Springer
Year
1990
Tongue
English
Weight
379 KB
Volume
85
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

✦ Synopsis

The aB-crystallin gene (CRYA2) encodes the abundant lens protein aB-crystallin. A panel of human/ rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of wellestablished human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster aB-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to llq12-11q23.

📜 SIMILAR VOLUMES

Human NK-2 receptor gene maps to chromos
Human NK-2 receptor gene maps to chromosome region 10q11–21
✍ John E. N. Morten; Brian Hopkins; Steven J. Powell; Alexander Graham 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 515 KB

The human NK-2 receptor gene has been mapped to chromosome 10 using the polymerase chain reaction to amplify specifically the human NK-2 receptor sequence in hamster/human hybrid DNA and also in mouse/human monochromosome hybrids. The assignment to chromosome 10 was confirmed by in situ hybridisatio

Chromosomal localization of the human hi
Chromosomal localization of the human histone H2A.X gene to 11q23.2-q23.3 by fluorescence in situ hybridization
✍ Vessela S. Ivanova; Drazen Zimonjic; Nicholas Popescu; William M. Bonner 📂 Article 📅 1994 🏛 Springer 🌐 English ⚖ 686 KB

The human histone H2A.X gene is unusual in that its transcripts are alternatively processed to yield two species, one a 0.6-kb replication-linked histone mRNA and the other a 1.6-kb polyadenylated mRNA. The H2A.X gene has been localized by fluorescence in situ hybridization to chromosome 11q23.2-q23