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Human urogastrone and mouse epidermal growth factor share a common receptor site in cultured human fibroblasts

✍ Scribed by Morley D. Hollenberg; Harold Gregory

Book ID
118937967
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
357 KB
Volume
20
Category
Article
ISSN
0024-3205

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## Abstract Epidermal growth factor is internalized into cells and concomitantly induces a massive clearance of up to 90% of its total surface receptors. The hormone‐receptor complex is delivered to lysosomes and degraded or inactivated. Lysosomotropic alkylamines block the degradation but not the