Human urinary excretion of doxifluridine and metabolites during a 5-day chemotherapeutic schedule using fluorine-19 nuclear magnetic resonance spectrometry
✍ Scribed by M. C. Malet-Martino; P. Servin; J. Bernadou; J. P. Armand; R. Martino
- Publisher
- Springer US
- Year
- 1987
- Tongue
- English
- Weight
- 443 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0167-6997
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✦ Synopsis
The urinary excretion of doxifluridine (5'dFUrd) and its metabolites was determined during five days of chemotherapy using fluorine-19 nuclear magnetic resonance spectrometry. The daily urinary excretion of 5' dFUrd and its metabolites was high (= 100~ of the 5' dFUrd administered) and nearly constant throughout the treatment. By far the major excreted compounds were unchanged 5' dFUrd and ~-fluoro-/3-alanine which made up respectively = 40070 and = 50o7o of the total. Neither accumulation of 5' dFUrd nor significant modifications in its metabolism were observed during the treatment.