𝔖 Bobbio Scriptorium
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Human tumor—lymphocyte interaction in vitro: Blastogenesis correlated to detectable immunoglobulin in the biopsy

✍ Scribed by F. Vánky; G. Trempe; E. Klein; J. Stjernswärd

Publisher
John Wiley and Sons
Year
1975
Tongue
French
Weight
726 KB
Volume
16
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Binding of radioiodinated anti‐immunoglobulin (Ig) reagent assayed by acid elutable radioactivity was shown in 18 of 44 cell suspensions (41%) prepared from surgical specimens of human tumors. Aliquots of these biopsies were admixed to autologous lymphocytes and in 13 cases they induced stimulation of DNA synthesis. In only one of these 13 cases was the anti‐Ig reagent bound, while among the 26 biopsies with low or no binding capacity 12 (46%) were stimulatory, indicating that immunoglobulin‐containing biopsies are not stimulatory. Experiments on 32 lymphocyte preparations from different lymphoid organs suggest that the immunoglobulin detected in the tumor‐cell suspension is not derived from the infiltrating lymphoid cells.

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Human tumor-lymphocyte interaction in vi
Human tumor-lymphocyte interaction in vitro. VII. Blastogenesis and generation of cytotoxicity against autologous tumor biopsy cells are inhibited by interferon
✍ F. Vánky; S. Argov 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 638 KB

## Abstract In a high proportion of cases blood lymphocytes from cancer patients cultured with autologous tumor biopsy cells undergo blastogenesis. In addition, cytotoxicity against autologous tumor cells is generated. These auto‐activated lymphocytes also kill the highly NK‐sensitive K‐562 and Mol