Human toxin-based recombinant immunotoxins/chimeric proteins as a drug delivery system for targeted treatment of human diseases

Selective targeting by preS1 domain of h

Selective targeting by preS1 domain of hepatitis B surface antigen conjugated with phosphorylcholine-based amphiphilic block copolymer micelles as a biocompatible, drug delivery carrier for treatment of human hepatocellular carcinoma with paclitaxel

✍ Ryohei Miyata; Masakazu Ueda; Hiromitsu Jinno; Tomohiro Konno; Kazuhiko Ishihara 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 474 KB

## Abstract Using dithioester‐capped 2‐methacryloyloxyethyl phosphorylcholine (MPC) as a macro chain transfer agent, a diblock copolymer was synthesized with __n__‐butyl methacrylate (BMA) as hydrophobic core‐forming blocks. The MPC–BMA unit was copolymerized with an immobilizable unit, __p__‐nitro