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Human thymidylate synthetase—III: Effects of methotrexate and folate analogs

✍ Scribed by Daniel W. Szeto; Cheng Yung-Chi; Andre Rosowsky; Yu Cheng-Sein; Edward J. Modest; James R. Piper; Carroll Temple Jr.; Robert D. Elliott; Jerry D. Rose; John A. Montgomery

Book ID
115774321
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
546 KB
Volume
28
Category
Article
ISSN
0006-2952

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## Abstract ## Objective Methotrexate (MTX) enters cells through the reduced folate carrier (RFC‐1) and exerts part of its effects through polyglutamation to MTX polyglutamates (MTXPGs) and inhibition of 5‐aminoimidazole‐4‐carboxamide ribonucleotide transformylase (ATIC) and thymidylate synthase (