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Human T lymphocytes and mast cells differentially express and regulate extra- and intracellular CXCR1 and CXCR2

✍ Scribed by Undine Lippert; Karolin Zachmann; Beate M. Henz; Christine Neumann

Book ID
110754971
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
278 KB
Volume
13
Category
Article
ISSN
0906-6705

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In this study we investigated the regulation of CXCR1 and CXCR2 intracellular trafficking. First, we produced a chimeric CXCR2 receptor that contained the internalization motifs of both CXCR2 and CXCR1 (CXCR2: LLKIL sequence; CXCR1: C-terminal phosphorylation sites). Elevated levels of internalizati