## Abstract Human immunodeficiency virus type 1 (HIV‐1) and human T‐cell lymphotropic virus types 1 and 2 (HTLV‐1 and ‐2) are retroviruses that share similar routes of transmission and some individuals may have a dual infection. These co‐infected subjects may be at increased risk for tropical spast
Human T-cell lymphotropic virus type 1 infection and tropical spastic paraparesis in belgian expatriates
✍ Scribed by Dr. P. Goubau; H. Carton; P. Cornet; G. Vercauteren; A. van Gompel; H. de Vooght; P. Piot; J. Desmyter
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 324 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0146-6615
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A case of HTLV‐1 associated tropical spastic paraparesis is described in a Belgian nun who had been working as a midwife in Central Africa. Occupational exposure was the only risk factor identified. Among 2,482 Belgian expatriates in tropical countries, 92% of whom had resided in sub‐Saharan Africa for an average of 15.5 years, only one Belgian‐born man was found seropositive for HTLV‐1. He was married t o an African woman and living in Central Africa for 23 years. The risk of HTLV‐1 infection is low in Belgian expatriates and on its own does not support generalised anti‐HTLV screening in autochthonous Belgian blood donors.
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## Abstract There is no effective therapy for human T‐cell lymphotropic virus type I (HTLV‐I)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). Glucocorticoids are effective to reduce the motor disability in these patients, but its role as anti‐spastic drugs is unknown. Here it is repor
## Abstract A high human T‐cell lymphotropic virus type 1 (HTLV‐1) proviral load is described in HTLV‐1‐associated diseases, especially HAM/TSP. However, the cut‐off value to define high levels of HTLV‐1 proviral load is not well established. 281 HTLV‐1‐infected patients from the HTLV reference cen
Tropical spastic paraparesis/HTLV-I associated myelopathy (TSP/HAM), is characterized by infiltration of human T cell leukaemia virus type-I (HTLV-I)-infected T-cells, anti-HTLV-I cytotoxic T cells and macrophages into the patients' cerebrospinal fluid and by intrathecally formed anti-HTLV-I antibod