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Human T Cell Activation Induces the Expression of a Novel CD45 Isoform That Is Analogous to Murine B220 and Is Associated with Altered O-Glycan Synthesis and Onset of Apoptosis

✍ Scribed by Jack J.H. Bleesing; Matthew R. Morrow; Gulbu Uzel; Thomas A. Fleisher

Book ID: 112240486
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 236 KB
Volume: 213
Category: Article
ISSN: 0008-8749
DOI: 10.1006/cimm.2001.1865

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## Abstract ## Background Differences between human and murine B cells exist at all stages of B‐cell development, including the stage of memory B‐cell formation. B cells in mice are identified with the pan–B‐cell–specific CD45 isoform, B220. In initial studies in humans, it appeared that B220 expr