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Human skin permeation of neutral species and ionic species: Extended linear free-energy relationship analyses

✍ Scribed by Keda Zhang; Ming Chen; Gerhard K. E. Scriba; Michael H. Abraham; Alfred Fahr; Xiangli Liu

Book ID: 112134488
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 213 KB
Volume: 101
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.23086

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✍ Michael H. Abraham; Filomena Martins 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 161 KB

Literature values of the permeability coefficient for permeation of human skin from water have been adjusted for ionization in water and adjusted for temperature. The obtained values of log K p for 119 solutes at 378C have been correlated with Abraham descriptors to yield an equation with R 2 ¼ 0.83