Human S100A4 (p9Ka) induces the metastatic phenotype upon benign tumour cells
β Scribed by Lloyd, Bryony H; Platt-Higgins, Angela; Rudland, Philip S; Barraclough, Roger
- Book ID
- 110061438
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 528 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0950-9232
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Rodent S100A4 (p9Ka) induces a metastatic phenotype in benign rat mammary tumour cells and cooperates with the neu oncogene to produce metastatic tumours in a transgenic mouse model system. Human S100A4 possesses similar metastasis-inducing properties. S100A4 mRNA is now sought in human breast tumou
Our aim was to compare the occurrence and prognostic significance over 14 -20 years of immunocytochemically detected S100A4 and other tumour variables in primary tumours from 349 patients with operable breast cancer. For a cut-off of 1% staining of the malignant cells, the antibody to S100A4 stains