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Human regulatory T cells and autoimmunity

✍ Scribed by Cristina M. Costantino; Clare M. Baecher-Allan; David A. Hafler

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
136 KB
Volume
38
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

CD4^+^CD25^+^ regulatory T cells (Treg) appear to be critical in regulating immune responses to self‐antigens. Treg deficiency is associated with several human autoimmune diseases. Although substantial progress has been made in the study of murine and human Treg, their fundamental mechanism of action remains unknown. In this review, we discuss the phenotype of human natural Treg, their functional mechanism, and their role in autoimmune disease.

See accompanying commentary: http://dx.doi.org/10.1002/eji.200738120

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